|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
34
|
|
pubmed:dateCreated |
1992-1-13
|
|
pubmed:databankReference |
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|
pubmed:abstractText |
The hepatitis B virus S (major surface gene) promoter is embedded in two overlapping open reading frames and specifies several transcripts with heterogeneous 5' termini. We have identified the cis-elements necessary for S promoter function. A single upstream CCAAT element is essential for high level expression in both liver and non-liver cells. No TATA box is present, but two regions surrounding the initiation sites can function separately as initiating elements. These results show that the S promoter has a simple requirement for upstream activating sequences, but a complex initiation region. Therefore, it may provide a suitable model system for studying transcription initiation in non-TATA type promoters.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
266
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
23416-21
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:1840596-Base Sequence,
pubmed-meshheading:1840596-DNA, Viral,
pubmed-meshheading:1840596-Hepatitis B Surface Antigens,
pubmed-meshheading:1840596-Hepatitis B virus,
pubmed-meshheading:1840596-Molecular Sequence Data,
pubmed-meshheading:1840596-Mutation,
pubmed-meshheading:1840596-Promoter Regions, Genetic,
pubmed-meshheading:1840596-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1840596-Transcription, Genetic
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
The hepatitis B virus S promoter comprises A CCAAT motif and two initiation regions.
|
|
pubmed:affiliation |
Department of Pathology, Veterans Affairs Medical Center, San Francisco, California.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
