Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-5-9
pubmed:abstractText
Interferon (IFN) gamma's ability to localise in the nucleus and function in gene activation has been known for some time, although the role of the conventional nuclear transporting importin molecules is unclear. Here, we demonstrate for the first time the direct recognition of IFNgamma and an IFNgamma mimetic peptide by IMPalpha and the IMPalpha/beta heterodimer, where the IFNgamma mimetic shows higher affinity. Significantly, this correlates well both with in vivo ability to target green fluorescent protein to the nucleus in transfected cells as determined by quantitative confocal laser scanning microscopy, as well as GAS promoter activity of a luciferase reporter. This has important implications for IFNgamma's anti-viral action, and the potential use of the IFNgamma mimetic in antiviral therapies.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-11080165, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-11563878, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-12135354, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-12165521, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-12764225, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-12799413, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-15122910, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-15351969, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-15702986, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-15827178, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-16103052, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-16171404, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-16434982, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-16785527, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-17085050, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-17690250, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-2943274, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-7945313, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-7991544, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-8910766, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-9202041, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-9268357, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-9268364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18405666-9867857
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
582
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1569-74
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic.
pubmed:affiliation
Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, P.O. Box 13D, Victoria, Clayton 3800, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural