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pubmed-article:18404268pubmed:abstractTextWe reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I. In the current study, we studied the potential of the high-energy alpha-emitter (211)At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of (131)I due to rapid iodide efflux.lld:pubmed
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pubmed-article:18404268pubmed:articleTitleThe potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer.lld:pubmed
pubmed-article:18404268pubmed:affiliationDepartment of Internal Medicine II, Ludwig-Maximilians-University, Munich, Germany.lld:pubmed
pubmed-article:18404268pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18404268pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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