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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-6-13
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pubmed:abstractText |
We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I. In the current study, we studied the potential of the high-energy alpha-emitter (211)At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of (131)I due to rapid iodide efflux.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1619-7070
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1272-81
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pubmed:meshHeading |
pubmed-meshheading:18404268-Animals,
pubmed-meshheading:18404268-Astatine,
pubmed-meshheading:18404268-Cell Line, Tumor,
pubmed-meshheading:18404268-Humans,
pubmed-meshheading:18404268-Male,
pubmed-meshheading:18404268-Mice,
pubmed-meshheading:18404268-Mice, Nude,
pubmed-meshheading:18404268-Neoplasm Transplantation,
pubmed-meshheading:18404268-Promoter Regions, Genetic,
pubmed-meshheading:18404268-Prostate-Specific Antigen,
pubmed-meshheading:18404268-Prostatic Neoplasms,
pubmed-meshheading:18404268-Recombinant Proteins,
pubmed-meshheading:18404268-Symporters,
pubmed-meshheading:18404268-Transfection,
pubmed-meshheading:18404268-Transplantation, Heterologous,
pubmed-meshheading:18404268-Tumor Stem Cell Assay
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pubmed:year |
2008
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pubmed:articleTitle |
The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer.
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pubmed:affiliation |
Department of Internal Medicine II, Ludwig-Maximilians-University, Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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