Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-4-28
pubmed:abstractText
The recent discovery of the angiotensin II (Ang II)-breakdown enzyme, angiotensin I converting enzyme (ACE) 2, suggests the importance of Ang II degradation in hypertension. The present study explored the signaling mechanism by which ACE2 is regulated under hypertensive conditions. Real-time PCR and immunohistochemistry showed that ACE2 mRNA and protein expression levels were high, whereas ACE expression levels were moderate in both normal kidney and heart. In contrast, patients with hypertension showed marked ACE up-regulation and ACE2 down-regulation in both hypertensive cardiopathy and, particularly, hypertensive nephropathy. The inhibition of ACE2 expression was shown to be associated with ACE up-regulation and activation of extracellular regulated (ERK)1/2 and p38 mitogen-activated protein (MAP) kinases. In vitro, Ang II was able to up-regulate ACE and down-regulate ACE2 in human kidney tubular cells, which were blocked by an angiotensin II (AT)1 receptor antagonist (losartan), but not by an AT2 receptor blocker (PD123319). Furthermore, blockade of ERK1/2 or p38 MAP kinases by either specific inhibitors or a dominant-negative adenovirus was able to abolish Ang II-induced ACE2 down-regulation in human kidney tubular cells. In conclusion, Ang II is able to up-regulate ACE and down-regulate ACE2 expression levels under hypertensive conditions both in vivo and in vitro. The AT1 receptor-mediated ERK/p38 MAP kinase signaling pathway may be a key mechanism by which Ang II down-regulates ACE2 expression, implicating an ACE/ACE2 imbalance in hypertensive cardiovascular and renal damage.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-10619573, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-10969042, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-12075344, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-12519920, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-12819233, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-14508196, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-14985062, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-15037565, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-15538735, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-15833808, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16049057, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16176966, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16216992, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16221218, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16331093, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16505206, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16520412, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16614314, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16723697, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-16878172, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-1730451, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-17499227, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-17579661, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-17878513, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-2669526, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-8040271, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-8144222, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-8311070, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-9249547, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-9453328, http://linkedlifedata.com/resource/pubmed/commentcorrection/18403595-9513899
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1525-2191
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1174-83
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18403595-Adult, pubmed-meshheading:18403595-Aged, pubmed-meshheading:18403595-Aged, 80 and over, pubmed-meshheading:18403595-Angiotensin II, pubmed-meshheading:18403595-Cell Line, pubmed-meshheading:18403595-Female, pubmed-meshheading:18403595-Gene Expression Regulation, pubmed-meshheading:18403595-Humans, pubmed-meshheading:18403595-Hypertension, pubmed-meshheading:18403595-Hypertension, Renal, pubmed-meshheading:18403595-Kidney, pubmed-meshheading:18403595-Male, pubmed-meshheading:18403595-Middle Aged, pubmed-meshheading:18403595-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:18403595-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:18403595-Myocardium, pubmed-meshheading:18403595-Organ Specificity, pubmed-meshheading:18403595-Peptidyl-Dipeptidase A, pubmed-meshheading:18403595-Receptor, Angiotensin, Type 1, pubmed-meshheading:18403595-Signal Transduction, pubmed-meshheading:18403595-p38 Mitogen-Activated Protein Kinases
pubmed:year
2008
pubmed:articleTitle
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway.
pubmed:affiliation
Department of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural