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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-5-29
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pubmed:abstractText |
Many methods for genotyping use melting temperature (Tm) of sequence-specific probes. Usually the probes hybridize to a continuous stretch of DNA that contains the variant(s). In contrast, hybridization of noncontinuous probes to a template can form bulges. This report generates guidelines for the design of noncontinuous probes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melanocortin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9147
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
990-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18403562-Base Sequence,
pubmed-meshheading:18403562-DNA,
pubmed-meshheading:18403562-Genetic Variation,
pubmed-meshheading:18403562-Genotype,
pubmed-meshheading:18403562-Haplotypes,
pubmed-meshheading:18403562-Hemoglobins,
pubmed-meshheading:18403562-Nucleic Acid Conformation,
pubmed-meshheading:18403562-Nucleic Acid Hybridization,
pubmed-meshheading:18403562-Oligonucleotide Probes,
pubmed-meshheading:18403562-Polymorphism, Single Nucleotide,
pubmed-meshheading:18403562-Receptor, Fibroblast Growth Factor, Type 3,
pubmed-meshheading:18403562-Receptor, Melanocortin, Type 1,
pubmed-meshheading:18403562-Receptors, Adrenergic, beta-2,
pubmed-meshheading:18403562-Software,
pubmed-meshheading:18403562-Thermodynamics,
pubmed-meshheading:18403562-Transition Temperature
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pubmed:year |
2008
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pubmed:articleTitle |
Design and application of noncontinuously binding probes used for haplotyping and genotyping.
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pubmed:affiliation |
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA. pontkig@aruplab.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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