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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-7-23
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pubmed:abstractText |
We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival. Overexpression of GRP78 in glioma cells decreases caspase 7 activation and renders the cells resistant to etoposide- and cisplatin-induced apoptosis, whereas silencing of GRP78 decreases cell growth and sensitizes glioma cells to etoposide, cisplatin, and gamma-radiation. Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-10760948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-10866344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-11895036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-12414657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-12665508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-14765377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-15261665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-16182273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-16297569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-16472112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-16618735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-16861902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-16912156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-17062670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-17106261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-17187227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-17440054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-17440086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18403493-17516742
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1522-8517
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
236-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18403493-Apoptosis,
pubmed-meshheading:18403493-Blotting, Western,
pubmed-meshheading:18403493-Brain Neoplasms,
pubmed-meshheading:18403493-Caspase 7,
pubmed-meshheading:18403493-Cell Line, Tumor,
pubmed-meshheading:18403493-Cell Proliferation,
pubmed-meshheading:18403493-Drug Resistance, Neoplasm,
pubmed-meshheading:18403493-Enzyme Activation,
pubmed-meshheading:18403493-Gene Expression,
pubmed-meshheading:18403493-Gene Expression Profiling,
pubmed-meshheading:18403493-Glioma,
pubmed-meshheading:18403493-Heat-Shock Proteins,
pubmed-meshheading:18403493-Humans,
pubmed-meshheading:18403493-Immunohistochemistry,
pubmed-meshheading:18403493-Molecular Chaperones,
pubmed-meshheading:18403493-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18403493-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18403493-Transfection,
pubmed-meshheading:18403493-Tumor Markers, Biological,
pubmed-meshheading:18403493-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
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pubmed:affiliation |
Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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