Linked Life Data

18403114

Source:http://linkedlifedata.com/resource/pubmed/id/18403114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-21
pubmed:abstractText
Altered calcium homeostasis is implicated in the pathogenesis of Alzheimer's disease (AD). Much effort has been put into understanding the association between protein mutations causative of this devastating neurodegenerative disease and perturbed calcium signaling. Whereas the presenilin mutations have received most attention in the context of neuronal calcium signaling, we focused on the effects of APP with the so-called Swedish mutation (APPswe) on spontaneous neuronal activity. We observed that primary hippocampal neurons from an APPswe transgenic rat showed increased frequency and unaltered amplitude of spontaneous calcium oscillations as compared to wild-type neurons. We found that the altered calcium signaling of APPswe transgenic neurons was unlikely to be due to modulation of the NMDA or nicotinic neurotransmitter systems, and did not depend on secreted APP derivates. The implications of this effect of APP are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
436
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
250-4
pubmed:dateRevised
2008-10-1
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons.
pubmed:affiliation
Karolinska Institutet, NVS Department, Div. Neurodegeneration, Novum Plan 5, 14186 Stockholm, Sweden. ewa.kloskowska@ki.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't