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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-4-23
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pubmed:abstractText |
The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymorphisms were investigated to determine if they modify risk in BRCA mutation carriers in breast cancer cases drawn from French Canadian cancer families, a population shown to exhibit strong founder effects.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18402691-Adult,
pubmed-meshheading:18402691-Canada,
pubmed-meshheading:18402691-Female,
pubmed-meshheading:18402691-Founder Effect,
pubmed-meshheading:18402691-France,
pubmed-meshheading:18402691-Genes, BRCA1,
pubmed-meshheading:18402691-Genes, BRCA2,
pubmed-meshheading:18402691-Genes, p53,
pubmed-meshheading:18402691-Genetic Predisposition to Disease,
pubmed-meshheading:18402691-Germ-Line Mutation,
pubmed-meshheading:18402691-Haplotypes,
pubmed-meshheading:18402691-Heterozygote,
pubmed-meshheading:18402691-Humans,
pubmed-meshheading:18402691-Middle Aged,
pubmed-meshheading:18402691-Polymorphism, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.
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pubmed:affiliation |
Department of Human Genetics, McGill University, Montreal, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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