| pubmed-article:18401419 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18401419 | lifeskim:mentions | umls-concept:C0079774 | lld:lifeskim |
| pubmed-article:18401419 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:18401419 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:18401419 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18401419 | pubmed:dateCreated | 2008-6-11 | lld:pubmed |
| pubmed-article:18401419 | pubmed:abstractText | Peripheral T-cell lymphomas (PTCLs) are fatal in the majority of patients and novel treatments, such as protein tyrosine kinase (PTK) inhibition, are needed. The recent finding of SYK/ITK translocations in rare PTCLs led us to examine the expression of Syk PTK in 141 PTCLs. Syk was positive by immunohistochemistry (IHC) in 133 PTCLs (94%), whereas normal T cells were negative. Western blot on frozen tissue (n=6) and flow cytometry on cell suspensions (n=4) correlated with IHC results in paraffin. Additionally, western blot demonstrated that Syk-positive PTCLs show tyrosine (525/526) phosphorylation, known to be required for Syk activation. Fluorescence in situ hybridization showed no SYK/ITK translocation in 86 cases. Overexpression of Syk, phosphorylation of its Y525/526 residues and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL. | lld:pubmed |
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| pubmed-article:18401419 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18401419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18401419 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18401419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18401419 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18401419 | pubmed:issn | 1476-5551 | lld:pubmed |
| pubmed-article:18401419 | pubmed:author | pubmed-author:MoraesN LNL | lld:pubmed |
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| pubmed-article:18401419 | pubmed:author | pubmed-author:SunD XDX | lld:pubmed |
| pubmed-article:18401419 | pubmed:author | pubmed-author:KurtinP JPJ | lld:pubmed |
| pubmed-article:18401419 | pubmed:author | pubmed-author:VranaJ AJA | lld:pubmed |
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| pubmed-article:18401419 | pubmed:author | pubmed-author:FinnS SSS | lld:pubmed |
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| pubmed-article:18401419 | pubmed:author | pubmed-author:NovakA JAJ | lld:pubmed |
| pubmed-article:18401419 | pubmed:author | pubmed-author:FeldmanA LAL | lld:pubmed |
| pubmed-article:18401419 | pubmed:author | pubmed-author:ThorlandE CEC | lld:pubmed |
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| pubmed-article:18401419 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18401419 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18401419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18401419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18401419 | pubmed:pagination | 1139-43 | lld:pubmed |
| pubmed-article:18401419 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:18401419 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18401419 | pubmed:articleTitle | Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas. | lld:pubmed |
| pubmed-article:18401419 | pubmed:affiliation | Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. feldman.andrew@mayo.edu | lld:pubmed |
| pubmed-article:18401419 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18401419 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18401419 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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