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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-6-11
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pubmed:abstractText |
Peripheral T-cell lymphomas (PTCLs) are fatal in the majority of patients and novel treatments, such as protein tyrosine kinase (PTK) inhibition, are needed. The recent finding of SYK/ITK translocations in rare PTCLs led us to examine the expression of Syk PTK in 141 PTCLs. Syk was positive by immunohistochemistry (IHC) in 133 PTCLs (94%), whereas normal T cells were negative. Western blot on frozen tissue (n=6) and flow cytometry on cell suspensions (n=4) correlated with IHC results in paraffin. Additionally, western blot demonstrated that Syk-positive PTCLs show tyrosine (525/526) phosphorylation, known to be required for Syk activation. Fluorescence in situ hybridization showed no SYK/ITK translocation in 86 cases. Overexpression of Syk, phosphorylation of its Y525/526 residues and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-10196263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-10689303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-10903730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-10931839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-11224611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-14984504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-15367405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-15744341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-15816054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-15914563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-15948116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-16341044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-16373702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-16409295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-16574771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-16835385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-16912221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-17122510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-17182546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-17460704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-17537677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-18006696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-8176201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18401419-9396765
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1476-5551
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pubmed:author |
pubmed-author:AttygalleA DAD,
pubmed-author:CaronB LBL,
pubmed-author:DoganAA,
pubmed-author:FeldmanA LAL,
pubmed-author:FinnS SSS,
pubmed-author:GroggK LKL,
pubmed-author:KurtinP JPJ,
pubmed-author:MaconW RWR,
pubmed-author:MoraesN LNL,
pubmed-author:NovakA JAJ,
pubmed-author:OttS LSL,
pubmed-author:RemsteinE DED,
pubmed-author:SunD XDX,
pubmed-author:ThorlandE CEC,
pubmed-author:VranaJ AJA
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1139-43
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:18401419-Adolescent,
pubmed-meshheading:18401419-Adult,
pubmed-meshheading:18401419-Aged,
pubmed-meshheading:18401419-Aged, 80 and over,
pubmed-meshheading:18401419-Blotting, Western,
pubmed-meshheading:18401419-Child,
pubmed-meshheading:18401419-Child, Preschool,
pubmed-meshheading:18401419-Chromosomes, Human, Pair 5,
pubmed-meshheading:18401419-Chromosomes, Human, Pair 9,
pubmed-meshheading:18401419-Female,
pubmed-meshheading:18401419-Flow Cytometry,
pubmed-meshheading:18401419-Humans,
pubmed-meshheading:18401419-Immunoenzyme Techniques,
pubmed-meshheading:18401419-Immunophenotyping,
pubmed-meshheading:18401419-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18401419-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18401419-Lymphoma, Extranodal NK-T-Cell,
pubmed-meshheading:18401419-Lymphoma, Large-Cell, Anaplastic,
pubmed-meshheading:18401419-Lymphoma, T-Cell, Cutaneous,
pubmed-meshheading:18401419-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:18401419-Male,
pubmed-meshheading:18401419-Middle Aged,
pubmed-meshheading:18401419-Phosphorylation,
pubmed-meshheading:18401419-Protein-Tyrosine Kinases,
pubmed-meshheading:18401419-Translocation, Genetic,
pubmed-meshheading:18401419-Tyrosine
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pubmed:year |
2008
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pubmed:articleTitle |
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas.
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pubmed:affiliation |
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. feldman.andrew@mayo.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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