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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-8-13
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pubmed:abstractText |
Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a vitamin K-dependent protein and a strong inhibitor of vascular calcification. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. We hypothesized that as a result of ucMGP deposition around arterial calcification, the circulating fraction of ucMGP is decreased. Here we report on the development of an ucMGP assay and the potential diagnostic utility of monitoring serum ucMGP levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0135
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pubmed:author |
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pubmed:copyrightInfo |
2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-36
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18401181-Adult,
pubmed-meshheading:18401181-Angioplasty,
pubmed-meshheading:18401181-Biological Markers,
pubmed-meshheading:18401181-Calcinosis,
pubmed-meshheading:18401181-Calciphylaxis,
pubmed-meshheading:18401181-Calcium-Binding Proteins,
pubmed-meshheading:18401181-Coronary Artery Disease,
pubmed-meshheading:18401181-Down-Regulation,
pubmed-meshheading:18401181-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18401181-Extracellular Matrix Proteins,
pubmed-meshheading:18401181-Female,
pubmed-meshheading:18401181-Germany,
pubmed-meshheading:18401181-Humans,
pubmed-meshheading:18401181-Male,
pubmed-meshheading:18401181-Middle Aged,
pubmed-meshheading:18401181-Netherlands,
pubmed-meshheading:18401181-Predictive Value of Tests,
pubmed-meshheading:18401181-Reference Values,
pubmed-meshheading:18401181-Renal Dialysis,
pubmed-meshheading:18401181-Renal Insufficiency,
pubmed-meshheading:18401181-Reproducibility of Results
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pubmed:year |
2008
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pubmed:articleTitle |
The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.
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pubmed:affiliation |
VitaK, Maastricht University, Maastricht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Multicenter Study,
Evaluation Studies
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