Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-5-30
pubmed:abstractText
Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expression has been studied in a wide range of human tumors in adults. We measured the expression of 12 CGGs in pediatric brain tumors, to identify targets for therapeutic cancer vaccines. Real Time PCR was used to quantify the expression of genes MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A10, MAGE-A12, MAGE-C2, NY-ESO-1 and GAGE-1,2,8 in 50 pediatric brain tumors of different histological subtypes. Protein expression was examined with immunohistochemistry. Fifty-five percent of the medulloblastomas (n = 11), 86% of the ependymomas (n = 7), 40% of the choroid plexus tumors (n = 5) and 67% of astrocytic tumors (n = 27) expressed one or more CGGs. Immunohistochemical analysis confirmed qPCR results. With exception of a minority of tumors, the overall level of CGG expression in pediatric brain tumors was low. We observed a high expression of at least one CGG in 32% of the samples. CGG-encoded antigens are therefore suitable targets in a very selected group of pediatric patients with a brain tumor. Interestingly, glioblastomas from adult patients expressed CGGs more often and at significantly higher levels compared to pediatric glioblastomas. This observation is in line with the notion that pediatric and adult glioblastomas develop along different genetic pathways.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-10379968, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-10601552, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-10842198, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-10868642, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-11051238, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-11290570, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-11351307, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-11357146, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-11751535, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12445281, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12494904, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12531359, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12876559, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12908754, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12952281, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-12962272, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-16034368, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-16197806, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-16758204, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-17019710, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-17143233, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-17618441, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-17682068, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-17957795, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-1840703, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-7617661, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-7757970, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-7800006, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-8011285, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-8084407, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-8302824, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-8509230, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-8885135, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-9176405, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-9210874, http://linkedlifedata.com/resource/pubmed/commentcorrection/18398575-9298216
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0167-594X
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Selective cancer-germline gene expression in pediatric brain tumors.
pubmed:affiliation
Department of Pediatric Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't