Linked Life Data

18397358

Source:http://linkedlifedata.com/resource/pubmed/id/18397358

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 4
pubmed:dateCreated
2008-6-26
pubmed:abstractText
Recently, the transcription factor-7-like 2 (TCF7L2) gene has been identified as the most important type 2 diabetes mellitus (T2DM) susceptibility gene. Common intronic polymorphisms in this gene have been found to be strongly associated with T2DM susceptibility showing marked reproducibility in multiple populations. The purpose of this study was to confirm the reported association of six TCF7L2 variants in a Khatri Sikh diabetic sample from North India. We genotyped six-associated SNPs in a case-control sample consisting of 556 T2DM cases and 537 controls. We also examined the impact of these variants on body mass index (BMI), waist to hip ratio (WHR), fasting insulin, and glucose and lipid levels. We report replication of association of four of the six SNPs with T2DM in this Khatri Sikh sample [rs7903146, (p = 0.010); rs11196205, (p = 0.011); rs10885409, (p = 0.002) and rs4918789, (p = 0.029)], under a dominant model conferring odds ratios (ORs) of 1.39, 1.44, 1.57 and 1.36, respectively. Haplotype analysis provided further evidence of association by showing a significant difference between cases and controls as revealed by the global omnibus test (chi(2)= 19.36; p = 0.0036). Multiple linear regression analysis also revealed the risk allele carriers of three of four significant SNPs (rs7903146, rs11196205, rs10885409) to be significantly associated with increased fasting total cholesterol (p value = 0.019, 0.025, 0.006) and LDL cholesterol levels (p value = 0.021, 0.018, 0.005), respectively. Our findings confirm that the TCF7L2 gene is a major risk factor for development of T2DM in Khatri Sikhs. It also provides new information about the significant impact of TCF7L2 gene variants on plasma cholesterol levels that appear to be independent of BMI.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
499-509
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:18397358-Adult, pubmed-meshheading:18397358-Aged, pubmed-meshheading:18397358-Blood Glucose, pubmed-meshheading:18397358-Body Mass Index, pubmed-meshheading:18397358-Case-Control Studies, pubmed-meshheading:18397358-Diabetes Mellitus, Type 2, pubmed-meshheading:18397358-Female, pubmed-meshheading:18397358-Genetic Predisposition to Disease, pubmed-meshheading:18397358-Genetic Variation, pubmed-meshheading:18397358-Haplotypes, pubmed-meshheading:18397358-Humans, pubmed-meshheading:18397358-India, pubmed-meshheading:18397358-Insulin, pubmed-meshheading:18397358-Lipids, pubmed-meshheading:18397358-Male, pubmed-meshheading:18397358-Middle Aged, pubmed-meshheading:18397358-Polymorphism, Single Nucleotide, pubmed-meshheading:18397358-Risk Factors, pubmed-meshheading:18397358-TCF Transcription Factors, pubmed-meshheading:18397358-Transcription Factor 7-Like 2 Protein
pubmed:year
2008
pubmed:articleTitle
TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels.
pubmed:affiliation
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. dharambir-sanghera@ouhsc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural