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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-5-19
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pubmed:abstractText |
Cisplatin (cisPt) is used as a chemotherapeutic agent for the treatment of a variety of human tumours; more recently, it has been demonstrated that tumour cell exposure to cisPt ultimately results in apoptosis, but the mechanism by which nuclear cisPt/DNA generates the cytoplasmic cascade of events involved has not been clarified. We have investigated the effects of cisPt on proliferation in the neuronal cell line B50, with particular attention being given to understand whether mitochondria are a target of cisPt and their involvement in the apoptotic process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1365-2184
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-20
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pubmed:meshHeading |
pubmed-meshheading:18397337-Animals,
pubmed-meshheading:18397337-Annexin A5,
pubmed-meshheading:18397337-Apoptosis,
pubmed-meshheading:18397337-Bromodeoxyuridine,
pubmed-meshheading:18397337-Caspase 9,
pubmed-meshheading:18397337-Cell Cycle,
pubmed-meshheading:18397337-Cell Line, Tumor,
pubmed-meshheading:18397337-Cell Proliferation,
pubmed-meshheading:18397337-Cisplatin,
pubmed-meshheading:18397337-Cytoskeleton,
pubmed-meshheading:18397337-DNA Fragmentation,
pubmed-meshheading:18397337-Enzyme Activation,
pubmed-meshheading:18397337-Flow Cytometry,
pubmed-meshheading:18397337-Fluorescein-5-isothiocyanate,
pubmed-meshheading:18397337-Immunohistochemistry,
pubmed-meshheading:18397337-Microscopy, Confocal,
pubmed-meshheading:18397337-Mitochondria,
pubmed-meshheading:18397337-Neurons,
pubmed-meshheading:18397337-Propidium,
pubmed-meshheading:18397337-Rats
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pubmed:year |
2008
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pubmed:articleTitle |
Cell proliferation, apoptosis and mitochondrial damage in rat B50 neuronal cells after cisplatin treatment.
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pubmed:affiliation |
Dipartimento di Biologia Animale, Università di Pavia, and Istituto di Genetica Moleculare, Sezione di Istochimica e Citochimica del CNR, Pavia, Italy. bottone@unipv.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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