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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-4
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pubmed:abstractText |
Indoleamine-2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme inducing suppression of T-cell function and immune tolerance. In hepatitis B virus (HBV) transgenic (Tg) mice, the adoptive transfer of HBV-specific cytotoxic T lymphocytes (CTL) causes a necroinflammatory liver disease that is histologically similar to acute viral hepatitis in man. The present study aimed to determine IDO expression in the liver and hepatocytes during an acute hepatitis model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1478-3231
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pubmed:author |
pubmed-author:AndoKazukiK,
pubmed-author:HaraAkiraA,
pubmed-author:ImawariMichioM,
pubmed-author:IshikawaTetsuyaT,
pubmed-author:ItoHiroyasuH,
pubmed-author:IwamotoNaokiN,
pubmed-author:MoriwakiHisatakaH,
pubmed-author:SaitoKuniakiK,
pubmed-author:SeishimaMitsuruM,
pubmed-author:TaguchiAyakoA,
pubmed-author:TakemuraMasaoM
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-83
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pubmed:meshHeading |
pubmed-meshheading:18397228-Alanine Transaminase,
pubmed-meshheading:18397228-Animals,
pubmed-meshheading:18397228-Hepatitis, Viral, Animal,
pubmed-meshheading:18397228-Hepatitis B virus,
pubmed-meshheading:18397228-Hepatocytes,
pubmed-meshheading:18397228-Immunohistochemistry,
pubmed-meshheading:18397228-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:18397228-Interferon-gamma,
pubmed-meshheading:18397228-Kynurenine,
pubmed-meshheading:18397228-Mice,
pubmed-meshheading:18397228-Mice, Transgenic,
pubmed-meshheading:18397228-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18397228-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:18397228-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo.
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pubmed:affiliation |
Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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