Linked Life Data

18394746

Source:http://linkedlifedata.com/resource/pubmed/id/18394746

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-4-28
pubmed:abstractText
Alternative splicing at donor or acceptor sites located just a few nucleotides apart is widespread in many species. It results in subtle changes in the transcripts and often in the encoded proteins. Several of these tandem splice events contribute to the repertoire of functionally different proteins, whereas many are neutral or deleterious. Remarkably, some of the functional events are differentially spliced in tissues or developmental stages, whereas others exhibit constant splicing ratios, indicating that function is not always associated with differential splicing. Stochastic splice site selection seems to play a major role in these processes. Here, we review recent progress in understanding functional and evolutionary aspects as well as the mechanism of splicing at short-distance tandem sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0168-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-55
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Widespread and subtle: alternative splicing at short-distance tandem sites.
pubmed:affiliation
Bioinformatics Group, Albert-Ludwigs-University Freiburg, 79110 Freiburg, Germany. hiller@informatik.uni-freiburg.de
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't