Source:http://linkedlifedata.com/resource/pubmed/id/18392618
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2008-9-23
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| pubmed:abstractText |
The thymus is the site where all T-cell precursors develop, mature, and subsequently leave as mature T-cells. Since the mechanisms that mediate and regulate thymic apoptosis are not fully understood, we utilized a syngenic GL261 murine glioma model to further elucidate the fate of T-cells in tumor bearing C57BL/6 mice. First, we found a dramatic reduction in the size of the thymus accompanied by a decrease in thymic cellularity in response to glioma growth in the brains of affected mice. There was a marked reduction of double positive subset and an increase in the frequency of CD4(+) and CD8(+) single positive T-cell subsets. Analysis of double negative thymocytes showed an increase in the accumulation of CD44(+) cells. In contrast, there was a marked loss of CD44 and CD122 expression in CD4(+) and CD8(+) subsets. The growth of intracranial tumors was also associated with decreased levels of HO-1, a mediator of anti-apoptotic function, and increased levels of Notch-1 and its ligand, Jagged-1. To determine whether thymic atrophy could be due to the effect of Notch and its ligand expression by glioma in vivo, we performed a bone marrow transplant experiment. Our results suggest that Notch-1 and its ligand Jagged-1 can induce apoptosis of thymocytes, thereby influencing thymic development, immune system homeostasis, and function of the immune cells in a model of experimental glioma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch1,
http://linkedlifedata.com/resource/pubmed/chemical/Serrate proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0340-7004
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
57
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1807-16
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| pubmed:meshHeading |
pubmed-meshheading:18392618-Animals,
pubmed-meshheading:18392618-Apoptosis,
pubmed-meshheading:18392618-Brain Neoplasms,
pubmed-meshheading:18392618-Calcium-Binding Proteins,
pubmed-meshheading:18392618-Cell Differentiation,
pubmed-meshheading:18392618-Disease Progression,
pubmed-meshheading:18392618-Flow Cytometry,
pubmed-meshheading:18392618-Glioma,
pubmed-meshheading:18392618-Heme Oxygenase-1,
pubmed-meshheading:18392618-Homeostasis,
pubmed-meshheading:18392618-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18392618-Male,
pubmed-meshheading:18392618-Membrane Proteins,
pubmed-meshheading:18392618-Mice,
pubmed-meshheading:18392618-Mice, Inbred C57BL,
pubmed-meshheading:18392618-Receptor, Notch1,
pubmed-meshheading:18392618-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18392618-T-Lymphocyte Subsets,
pubmed-meshheading:18392618-T-Lymphocytes,
pubmed-meshheading:18392618-Thymus Gland
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| pubmed:year |
2008
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| pubmed:articleTitle |
Progression of intracranial glioma disrupts thymic homeostasis and induces T-cell apoptosis in vivo.
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| pubmed:affiliation |
The Brain Tumor Center, The University of Chicago, 5841 S. Maryland Ave MC 3026, Chicago, IL, 60637, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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