18390737

Source:http://linkedlifedata.com/resource/pubmed/id/18390737

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0024204, umls-concept:C0037224, umls-concept:C0039198, umls-concept:C0042769, umls-concept:C0079189, umls-concept:C0127400, umls-concept:C0282554, umls-concept:C0450254, umls-concept:C1517945
pubmed:issue	8
pubmed:dateCreated	2008-4-8
pubmed:abstractText	Regulatory T cells (T(reg)) play key roles in immune regulation through multiple modes of suppression. The effects of HIV-1 infection on T(reg) levels in lymphoid tissues remain incompletely understood. To explore this issue, we have measured the levels of forkhead box protein 3 (FOXP3)-positive cells and associated immunomodulatory genes in a pathogenic simian immunodeficiency virus/macaque model and found that a loss of T(reg) in lymph nodes occurred following simian immunodeficiency virus infection. Changes in expression of the ligands for CXCR3, CCR4, and CCR7 and the cytokines TGF-beta and IL-2 were all linked to this loss of T(reg), which in turn was linked with increased levels of cellular activation. Our findings identify three mechanisms that likely contribute to SIV-driven loss of T(reg), including reduced levels of cytokines associated with T(reg) differentiation and altered expression of agonist and antagonist chemokines. The loss of T(reg) and the associated cellular activation in lymphoid tissues is consistent with the events in HIV-1-infected individuals and suggest that components of the T(reg) differentiation and trafficking network could be targets for therapeutic intervention.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI060422, http://linkedlifedata.com/resource/pubmed/grant/HL072682, http://linkedlifedata.com/resource/pubmed/grant/R01 AI060422-02, http://linkedlifedata.com/resource/pubmed/grant/R01 HL072682-01, http://linkedlifedata.com/resource/pubmed/grant/U54 RR022241-01, http://linkedlifedata.com/resource/pubmed/grant/U54 RR02241
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-11272893, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-11964273, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-12522256, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-12648460, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-12848988, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-12884299, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-12960820, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-12975455, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-15163733, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-15749840, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-15761496, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-15778406, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-15879087, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-16210637, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-16453267, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-16818738, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-16902147, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-16903903, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-16903920, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17023422, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17192467, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17277105, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17289675, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17314162, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17371928, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17474313, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17548521, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-17620361, http://linkedlifedata.com/resource/pubmed/commentcorrection/18390737-3012358
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985117R
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR4, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0022-1767
pubmed:author	pubmed-author:Barratt-BoyesSimon MSM, pubmed-author:JuneckoBeth A FallertBA, pubmed-author:KirschnerDenise EDE, pubmed-author:Murphey-CorbMichael AMA, pubmed-author:PeaseJames EJE, pubmed-author:QinShulinS, pubmed-author:ReinhartTodd ATA, pubmed-author:SoloffAdam CAC, pubmed-author:SuiYongjunY, pubmed-author:TarwaterPatrick MPM, pubmed-author:WatkinsSimon CSC
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	180
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5530-6
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:18390737-Animals, pubmed-meshheading:18390737-Cytokines, pubmed-meshheading:18390737-Disease Models, Animal, pubmed-meshheading:18390737-Forkhead Transcription Factors, pubmed-meshheading:18390737-Interleukin-2, pubmed-meshheading:18390737-Ligands, pubmed-meshheading:18390737-Lymph Nodes, pubmed-meshheading:18390737-Macaca fascicularis, pubmed-meshheading:18390737-Receptors, CCR4, pubmed-meshheading:18390737-Receptors, CCR7, pubmed-meshheading:18390737-Receptors, CXCR3, pubmed-meshheading:18390737-Simian Acquired Immunodeficiency Syndrome, pubmed-meshheading:18390737-Simian immunodeficiency virus, pubmed-meshheading:18390737-T-Lymphocytes, Regulatory, pubmed-meshheading:18390737-Transforming Growth Factor beta
pubmed:year	2008
pubmed:articleTitle	Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection.
pubmed:affiliation	Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural