Source:http://linkedlifedata.com/resource/pubmed/id/18390713
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2008-4-8
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pubmed:abstractText |
Homeostatic proliferation for naive T cells is observed readily only under lymphopenic conditions in response to elevated levels of IL-7 and contact with self-MHC/peptide ligands. Homeostatic proliferation occurs at a slow pace and gradually induces the dividing cells to acquire characteristics of memory cells. We describe a novel type of homeostatic proliferation whereby naive T cells proliferate at a significantly faster rate, resembling the proliferation speed induced by foreign Ags, and the expanding cells rapidly differentiate into central memory cells. Remarkably, such rapid homeostatic proliferation is driven by a combination of IL-2 and IL-15, with IL-15 playing a bigger role, and applies for a wide repertoire of CD8(+) naive T cells, including many TCR-transgenic lines, even those that fail to undergo IL-7-driven homeostatic proliferation. Thus, naive T cells can be induced to undergo homeostatic proliferation of variable speed with a few members of the common gamma-chain (CD132) family of cytokines, the speed of proliferation depending on the levels of the particular cytokine involved.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG001743,
http://linkedlifedata.com/resource/pubmed/grant/AG020186,
http://linkedlifedata.com/resource/pubmed/grant/AI007244,
http://linkedlifedata.com/resource/pubmed/grant/AI045809,
http://linkedlifedata.com/resource/pubmed/grant/AI046710,
http://linkedlifedata.com/resource/pubmed/grant/AI064586,
http://linkedlifedata.com/resource/pubmed/grant/T32 AI07244
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5320-6
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pubmed:meshHeading |
pubmed-meshheading:18390713-Animals,
pubmed-meshheading:18390713-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18390713-Cell Proliferation,
pubmed-meshheading:18390713-Homeostasis,
pubmed-meshheading:18390713-Interleukin Receptor Common gamma Subunit,
pubmed-meshheading:18390713-Interleukin-15,
pubmed-meshheading:18390713-Interleukin-2,
pubmed-meshheading:18390713-Interleukin-7,
pubmed-meshheading:18390713-Lymphocyte Activation,
pubmed-meshheading:18390713-Mice,
pubmed-meshheading:18390713-Mice, Inbred C57BL,
pubmed-meshheading:18390713-Mice, Mutant Strains,
pubmed-meshheading:18390713-Mice, Transgenic
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pubmed:year |
2008
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pubmed:articleTitle |
The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.
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pubmed:affiliation |
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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