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rdf:type |
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lifeskim:mentions |
umls-concept:C0010656,
umls-concept:C0021753,
umls-concept:C0030685,
umls-concept:C0037564,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0806987,
umls-concept:C1283071,
umls-concept:C1378554,
umls-concept:C1522240,
umls-concept:C1963578,
umls-concept:C2349975
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-13
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pubmed:abstractText |
Recent studies suggest that crystals of monosodium urate (MSU), deposited in joints of patients with acute gouty arthritis, activate the NACHT domain, leucine-rich repeat and pyrin domain-containing protein (NALP)3 inflammasome. In the present study we have investigated whether production of proinflammatory cytokines by crystals was exacerbated during costimulation with Toll-like receptor (TLR) ligands.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NLRP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Uric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1468-2060
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-8
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pubmed:meshHeading |
pubmed-meshheading:18390571-Adult,
pubmed-meshheading:18390571-Carrier Proteins,
pubmed-meshheading:18390571-Caspase 1,
pubmed-meshheading:18390571-Cells, Cultured,
pubmed-meshheading:18390571-Crystallization,
pubmed-meshheading:18390571-Cytokines,
pubmed-meshheading:18390571-Dose-Response Relationship, Immunologic,
pubmed-meshheading:18390571-Female,
pubmed-meshheading:18390571-Gene Expression Regulation,
pubmed-meshheading:18390571-Humans,
pubmed-meshheading:18390571-Inflammation Mediators,
pubmed-meshheading:18390571-Interleukin-1beta,
pubmed-meshheading:18390571-Leukocytes, Mononuclear,
pubmed-meshheading:18390571-Lipopolysaccharides,
pubmed-meshheading:18390571-Male,
pubmed-meshheading:18390571-Mutation,
pubmed-meshheading:18390571-Polymerase Chain Reaction,
pubmed-meshheading:18390571-RNA, Messenger,
pubmed-meshheading:18390571-Uric Acid,
pubmed-meshheading:18390571-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process.
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pubmed:affiliation |
Department of Internal Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands. giamarel@ath.forthnet.gr
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pubmed:publicationType |
Journal Article
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