Source:http://linkedlifedata.com/resource/pubmed/id/18388182
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2008-6-11
|
| pubmed:abstractText |
Gammadelta T cells play an important role in innate immunity against infections; however, the regulation of these cells remains largely unknown. In the present study, we show that ESAT-6, an antigen of Mycobacterium tuberculosis, induces IFN-gamma secretion by human gammadelta T cells. In addition, ESAT-6 also induces the activation and proliferation of gammadelta T cells. Phenotypic analysis indicates that IFN-gamma-producing gammadelta T cells are mainly effector memory cells with the surface phenotype of CD45RA(-)CD62L(-)CCR7(-). These results were further confirmed by the fact that naive gammadelta T cells from cord blood did not produce IFN-gamma in response to ESAT-6. Further studies indicated that stimulation with ESAT-6 directly induced purified gammadelta T cells to produce IFN-gamma, independent of both antigen-presenting cells and CD4(+) T cells. Unexpectedly, depletion of CD4(+) T cells markedly enhanced IFN-gamma production by gammadelta T cells, indicating that CD4(+) T cells regulate the response of gammadelta T cells. Importantly, CD4(+)CD25(+) T regulatory (Treg) cells but not CD4(+)CD25(-) T cells significantly inhibited IFN-gamma production by gammadelta T cells. Taken together, these data demonstrate for the first time that Treg cells can play an important role in the regulation of immune responses of antigen-specific human memory gammadelta T cells.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ESAT-6 protein, Mycobacterium...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1528-0020
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5629-36
|
| pubmed:dateRevised |
2009-1-12
|
| pubmed:meshHeading |
pubmed-meshheading:18388182-Adolescent,
pubmed-meshheading:18388182-Adult,
pubmed-meshheading:18388182-Antigens, Bacterial,
pubmed-meshheading:18388182-Antigens, CD4,
pubmed-meshheading:18388182-Bacterial Proteins,
pubmed-meshheading:18388182-Cell Communication,
pubmed-meshheading:18388182-Cells, Cultured,
pubmed-meshheading:18388182-Female,
pubmed-meshheading:18388182-Humans,
pubmed-meshheading:18388182-Immunologic Memory,
pubmed-meshheading:18388182-Interferon-gamma,
pubmed-meshheading:18388182-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:18388182-Male,
pubmed-meshheading:18388182-Middle Aged,
pubmed-meshheading:18388182-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:18388182-T-Lymphocyte Subsets,
pubmed-meshheading:18388182-T-Lymphocytes, Regulatory,
pubmed-meshheading:18388182-Tuberculosis
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
CD4+ CD25+ Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6.
|
| pubmed:affiliation |
Department of Immunology, Zhongshan School of Medicine, Key Laboratory of Tropical Disease Control Research of Ministry of Education, Sun Yat-Sen University, Guangzhou, China.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|