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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-5-5
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pubmed:abstractText |
Compounds 2a- h and 6 displayed significant GI 50 values of 10(-7)-10(-6) M against various cancer cell lines. Of these compounds, 2-(6-(2-trifluoromethylphenyl))-3(Z)-hexen-1,5-diynyl)aniline (2c) showed the most potent growth inhibition activity. Compound 2c also arrested cancer cells in the G2/M phase and in low concentration reduced a significant percentage of MDA-MB-231/ATCC breast cancer tetraploid cells. In addition to the G2/M block, compound 2c caused microtubule depolymerization and induced apoptosis via activation of the caspase family.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:ChangLong-SenLS,
pubmed-author:DuhTsai-HuiTH,
pubmed-author:HongYi-RenYR,
pubmed-author:LinChi-FongCF,
pubmed-author:LinChing-ChihCC,
pubmed-author:LinShinne-RenSR,
pubmed-author:LinYing-TingYT,
pubmed-author:LoYu-HsiangYH,
pubmed-author:WuMing-JungMJ,
pubmed-author:YangSheng-HueiSH,
pubmed-author:YangShyh-ChyunSC
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2682-8
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pubmed:meshHeading |
pubmed-meshheading:18386884-Aniline Compounds,
pubmed-meshheading:18386884-Biopolymers,
pubmed-meshheading:18386884-Cell Cycle,
pubmed-meshheading:18386884-Cell Line, Tumor,
pubmed-meshheading:18386884-Cell Proliferation,
pubmed-meshheading:18386884-Drug Screening Assays, Antitumor,
pubmed-meshheading:18386884-Humans,
pubmed-meshheading:18386884-Microtubules,
pubmed-meshheading:18386884-Stereoisomerism,
pubmed-meshheading:18386884-Structure-Activity Relationship,
pubmed-meshheading:18386884-Tubulin,
pubmed-meshheading:18386884-Tubulin Modulators
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pubmed:year |
2008
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pubmed:articleTitle |
2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents.
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pubmed:affiliation |
Graduate Institute of Pharmaceutical Sciences, Graduate Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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