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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-3-26
|
| pubmed:abstractText |
The dopamine hypothesis for Tourette's syndrome proposes that the disorder is pathologically related either to an excessive amount of dopamine or to supersensitive receptors. To evaluate these proposals, pre- and postsynaptic markers of dopamine metabolism were measured in postmortem striatum from three adults with the diagnosis of Tourette's syndrome. Neuronal dopamine uptake carrier sites [( 3H]mazindol binding) were significantly increased in number over control values by 37% in the caudate and by 50% in the putamen. High-pressure liquid chromatographic assays of dopamine and its primary metabolites, homovanillic acid and 3,4-dihydroxyphenylacetic acid, showed normal findings. D1 and D2 subtypes of dopaminergic receptors [( 3H]SCH 23390 and [3H]spiperone binding, respectively) showed only slight alterations, presumably due to treatment with neuroleptics. The concentration of adenosine 3',5'-monophosphate (cyclic AMP) in putamen was reduced by 23%. Our data support earlier proposals of a dopaminergic abnormality in TS, but suggest that the mechanism involves a significant alteration of uptake sites. We speculate that increases in carrier site binding indicate an enhanced dopamine innervation within the striatum.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dihydroxyphenylacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Homovanillic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0364-5134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
558-62
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1838678-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:1838678-Adult,
pubmed-meshheading:1838678-Caudate Nucleus,
pubmed-meshheading:1838678-Chromatography, High Pressure Liquid,
pubmed-meshheading:1838678-Corpus Striatum,
pubmed-meshheading:1838678-Dopamine,
pubmed-meshheading:1838678-Female,
pubmed-meshheading:1838678-Homovanillic Acid,
pubmed-meshheading:1838678-Humans,
pubmed-meshheading:1838678-Kinetics,
pubmed-meshheading:1838678-Male,
pubmed-meshheading:1838678-Middle Aged,
pubmed-meshheading:1838678-Putamen,
pubmed-meshheading:1838678-Radioligand Assay,
pubmed-meshheading:1838678-Receptors, Dopamine,
pubmed-meshheading:1838678-Receptors, Dopamine D1,
pubmed-meshheading:1838678-Receptors, Dopamine D2,
pubmed-meshheading:1838678-Tourette Syndrome
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome.
|
| pubmed:affiliation |
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|