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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-5-21
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pubmed:abstractText |
Numerous and compelling evidence shows that high level of reactive oxygen species (ROS) plays a key role in prostate cancer occurrence, recurrence and progression. The molecular mechanism of ROS overproduction in the prostate gland, however, remains mostly unknown. Unique AP-1 transcription factor JunD has been shown to inhibit cell proliferation, promote differentiation and mediate stress responses in a variety of eukaryotic cells. We previously reported that androgen-androgen receptor induced ROS production in androgen-dependent LNCaP human prostate cancer cells is associated with increased JunD level/AP-1 transcriptional activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
924-34
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pubmed:meshHeading |
pubmed-meshheading:18386285-Blotting, Western,
pubmed-meshheading:18386285-Cell Line, Tumor,
pubmed-meshheading:18386285-Genetic Vectors,
pubmed-meshheading:18386285-Hormone Antagonists,
pubmed-meshheading:18386285-Humans,
pubmed-meshheading:18386285-Male,
pubmed-meshheading:18386285-Metribolone,
pubmed-meshheading:18386285-Neoplasms, Hormone-Dependent,
pubmed-meshheading:18386285-Oxidative Stress,
pubmed-meshheading:18386285-Prostatic Neoplasms,
pubmed-meshheading:18386285-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:18386285-RNA, Neoplasm,
pubmed-meshheading:18386285-RNA, Small Interfering,
pubmed-meshheading:18386285-Reactive Oxygen Species,
pubmed-meshheading:18386285-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18386285-Transcription Factor AP-1,
pubmed-meshheading:18386285-Transduction, Genetic,
pubmed-meshheading:18386285-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells.
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pubmed:affiliation |
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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