Linked Life Data

18386227

Source:http://linkedlifedata.com/resource/pubmed/id/18386227

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-3
pubmed:abstractText
Micro (mi)RNAs are small, regulatory RNA molecules that are integral components of the genetic program in the majority of cells. They are thought to regulate up to one third of all human genes and have been linked to critical processes in disease pathogenesis. The diverse role of miRNAs in disease pathogenesis suggests that the modulation of miRNA function by utilizing techniques such as the use of antagomirs, locked nucleic acids, or miRNA sponges may produce novel therapeutic approaches. In this review, the current understanding of post-transcriptional gene regulation by miRNAs is discussed and insights into the function of miRNAs in tumorigenesis, immune responses, muscle function, organogenesis, and cell-lineage decisions are reviewed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-8431
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
150-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Emerging role of microRNAs in disease pathogenesis and strategies for therapeutic modulation.
pubmed:affiliation
University of Newcastle, Faculty of Health and Hunter Medical Research Institute, School of Biomedical Sciences, Centre for Asthma and Respiratory Diseases, Newcastle, NSW 2300, Australia. joerg.mattes@newcastle.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't