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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1992-3-19
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pubmed:abstractText |
The effect of Escherichia coli lipopolysaccharide (LPS) on the competence of pulmonary macrophages and phagocytic cells from the systemic circulation of turkeys was examined using luminol-enhanced zymosan-stimulated chemiluminescence. The results showed a rapid and accelerated oxidative burst in both systemic and pulmonary macrophages in LPS-treated turkeys that was significantly greater than in untreated controls. However, this increased oxidative metabolism induced by LPS was not associated with enhanced intracellular bacterial killing by pulmonary macrophages. Turkeys treated with LPS showed a highly significant decrease in pulmonary bactericidal activity against Staphylococcus aureus challenge, indicating a defect in pulmonary macrophage function induced by LPS.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0005-2086
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
901-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1838477-Animals,
pubmed-meshheading:1838477-Endotoxins,
pubmed-meshheading:1838477-Escherichia coli,
pubmed-meshheading:1838477-Lethal Dose 50,
pubmed-meshheading:1838477-Lipopolysaccharides,
pubmed-meshheading:1838477-Liver,
pubmed-meshheading:1838477-Luminescent Measurements,
pubmed-meshheading:1838477-Lung,
pubmed-meshheading:1838477-Macrophages, Alveolar,
pubmed-meshheading:1838477-Oxidation-Reduction,
pubmed-meshheading:1838477-Phagocytosis,
pubmed-meshheading:1838477-Respiratory Burst,
pubmed-meshheading:1838477-Specific Pathogen-Free Organisms,
pubmed-meshheading:1838477-Staphylococcus aureus,
pubmed-meshheading:1838477-Turkeys
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pubmed:articleTitle |
Endotoxin lipopolysaccharide from Escherichia coli and its effects on the phagocytic function of systemic and pulmonary macrophages in turkeys.
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pubmed:affiliation |
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
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pubmed:publicationType |
Journal Article
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