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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-3-19
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pubmed:abstractText |
Rats were trained to self-administer cocaine on a fixed-ratio 5 schedule of reinforcement with a 1-min time-out period following each infusion. Cocaine was available at doses of either 0.1, 0.3 or 1.0 mg/kg/infusion. A low dose (3 microgram/kg) of the D1 antagonist SCH23390 caused an increase in cocaine self-administration which was more prominent at higher, as compared to lower, doses of cocaine. Higher doses of SCH23390 generally caused decreases in self-administration which may in part be due to the response-decreasing properties of this agent. The D2 antagonist spiperone generally caused an increase in self-administration of cocaine. These data suggest that cocaine reinforcement depends upon both D1 and D2 receptor subtypes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0091-3057
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
799-802
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1838414-Animals,
pubmed-meshheading:1838414-Benzazepines,
pubmed-meshheading:1838414-Cocaine,
pubmed-meshheading:1838414-Conditioning, Operant,
pubmed-meshheading:1838414-Dopamine Antagonists,
pubmed-meshheading:1838414-Dose-Response Relationship, Drug,
pubmed-meshheading:1838414-Male,
pubmed-meshheading:1838414-Rats,
pubmed-meshheading:1838414-Receptors, Dopamine D1,
pubmed-meshheading:1838414-Receptors, Dopamine D2,
pubmed-meshheading:1838414-Reinforcement (Psychology),
pubmed-meshheading:1838414-Self Administration,
pubmed-meshheading:1838414-Spiperone
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pubmed:year |
1991
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pubmed:articleTitle |
Cocaine self-administration is increased by both D1 and D2 dopamine antagonists.
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pubmed:affiliation |
Addiction Research Foundation, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article
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