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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-5-21
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pubmed:abstractText |
Interferon-alpha2 (IFNalpha2) is routinely used for anti-hepatitis B virus (HBV) treatment. However, the therapeutic efficiency is unsatisfactory, particularly in East Asia. Such inefficiency might be a result of the short half-life, relatively low local concentration and strong side-effects of interferons. Frequent and repeated injection is also a big burden for patients. In the present study, a single dose of vector-delivered IFNalpha1 was tested for its anti-HBV effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1521-2254
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pubmed:author |
pubmed-author:ChanChu-yanCY,
pubmed-author:ChenYangchaoY,
pubmed-author:DongQingmingQ,
pubmed-author:HeMing-LiangML,
pubmed-author:HuangJian-dongJD,
pubmed-author:KungHsiang-fuHF,
pubmed-author:LiZhiZ,
pubmed-author:LinMarie CMC,
pubmed-author:PengYingY,
pubmed-author:SungJoseph JJJ,
pubmed-author:WinNN,
pubmed-author:YaoHongH,
pubmed-author:YuenKwok YunKY,
pubmed-author:ZhengBo-jianBJ
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-27
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pubmed:meshHeading |
pubmed-meshheading:18383553-Animals,
pubmed-meshheading:18383553-Blotting, Western,
pubmed-meshheading:18383553-Cells, Cultured,
pubmed-meshheading:18383553-Dependovirus,
pubmed-meshheading:18383553-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18383553-Gene Expression Regulation, Viral,
pubmed-meshheading:18383553-Genetic Vectors,
pubmed-meshheading:18383553-Hepatitis B,
pubmed-meshheading:18383553-Hepatitis B Antigens,
pubmed-meshheading:18383553-Hepatitis B virus,
pubmed-meshheading:18383553-Immunotherapy,
pubmed-meshheading:18383553-Interferon-alpha,
pubmed-meshheading:18383553-Mice,
pubmed-meshheading:18383553-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of HBV gene expression and replication by stably expressed interferon-alpha1 via adeno-associated viral vectors.
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pubmed:affiliation |
Department of Microbiology, The University of Hong Kong, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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