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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017431,
umls-concept:C0030685,
umls-concept:C0079189,
umls-concept:C0205112,
umls-concept:C0205225,
umls-concept:C0205409,
umls-concept:C0391871,
umls-concept:C0441889,
umls-concept:C0680255,
umls-concept:C1121402,
umls-concept:C1283071,
umls-concept:C1321301,
umls-concept:C1826449,
umls-concept:C1963578,
umls-concept:C2698415
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|
pubmed:issue |
8
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pubmed:dateCreated |
2008-7-17
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|
pubmed:abstractText |
The functional link between mutations in NOD2 and Crohn's disease (CD) has not been entirely elucidated. The 1007fs mutation results in loss of NF-kappaB activation in response to muramyl dipeptide (MDP) but has also been linked to an increased IL-1beta processing and IL-12 release.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
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pubmed:issn |
1536-4844
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|
pubmed:author |
pubmed-author:BeynonVanessaV,
pubmed-author:BrandStephanS,
pubmed-author:CotofanaSebastianS,
pubmed-author:FolwacznyChristianC,
pubmed-author:FolwacznyMatthiasM,
pubmed-author:GlasJürgenJ,
pubmed-author:LohsePeterP,
pubmed-author:MairAnjaA,
pubmed-author:MussackThomasT,
pubmed-author:OchsenkühnThomasT,
pubmed-author:TörökHelga-PaulaHP,
pubmed-author:WagnerStefanieS
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|
pubmed:issnType |
Electronic
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pubmed:volume |
14
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1033-40
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pubmed:meshHeading |
pubmed-meshheading:18383179-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:18383179-Adjuvants, Immunologic,
pubmed-meshheading:18383179-Case-Control Studies,
pubmed-meshheading:18383179-Crohn Disease,
pubmed-meshheading:18383179-Dose-Response Relationship, Drug,
pubmed-meshheading:18383179-Female,
pubmed-meshheading:18383179-Genotype,
pubmed-meshheading:18383179-Humans,
pubmed-meshheading:18383179-Interleukin-10,
pubmed-meshheading:18383179-Interleukin-12 Subunit p40,
pubmed-meshheading:18383179-Interleukin-1beta,
pubmed-meshheading:18383179-Male,
pubmed-meshheading:18383179-Monocytes,
pubmed-meshheading:18383179-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:18383179-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes.
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pubmed:affiliation |
Department of Surgery, Innenstadt, University of Munich, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
