Linked Life Data

1838252

Source:http://linkedlifedata.com/resource/pubmed/id/1838252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-3-10
pubmed:abstractText
The aim of the present study was to show by hemodynamic investigations in a rat heart and by theoretical considerations based on different heart models that a chronic enlargement of the heart does not necessarily lead to an impairment of the stroke volume. In the experiments performed on rat hearts of various sizes, in situ pressure-volume diagrams were obtained which clearly demonstrate that, in principle, larger hearts are able to eject larger stroke volumes despite the fact that for geometrical reasons, they have to develop higher wall stress. These findings are supported by calculations of stroke volume-heart size relations being based on the assumption of different geometrical models for the left ventricle. By means of these relations, when applying them to pressure-volume data of a dilated or failing heart, it is in principle possible to differentiate between effects of altered geometry and of altered contractility. A simple lever-pump system is introduced which is appropriate to simulate transmission aspects in the transformation of myocardial shortening into ventricular ejection for hearts of variable size.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0300-8428
pubmed:author
pubmed:issnType
Print
pubmed:volume
86 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-54
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Principal considerations on the stroke volume-heart size relationship based on different heart models.
pubmed:affiliation
Physiologisches Institut II, Universität Tübingen, FRG.
pubmed:publicationType
Journal Article