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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-6-3
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pubmed:abstractText |
We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0891-3668
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pubmed:author |
pubmed-author:ButlerKarinaK,
pubmed-author:ChakrabortyRanaR,
pubmed-author:Collaborative HIV Paediatric Study,
pubmed-author:DoerholtKatjaK,
pubmed-author:DunnDavidD,
pubmed-author:DuongTrinhT,
pubmed-author:GibbDiD,
pubmed-author:GreenHannahH,
pubmed-author:LyallHermioneH,
pubmed-author:PillayDeenanD,
pubmed-author:RiordonAndrewA,
pubmed-author:SabinCaroline ACA,
pubmed-author:SmithColette JCJ,
pubmed-author:TookeyPatP,
pubmed-author:UK Collaborative Group on HIV Drug Resistance
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-9
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pubmed:meshHeading |
pubmed-meshheading:18382385-Adolescent,
pubmed-meshheading:18382385-Adult,
pubmed-meshheading:18382385-Amino Acid Substitution,
pubmed-meshheading:18382385-Child,
pubmed-meshheading:18382385-Child, Preschool,
pubmed-meshheading:18382385-Cohort Studies,
pubmed-meshheading:18382385-Drug Resistance, Viral,
pubmed-meshheading:18382385-Genotype,
pubmed-meshheading:18382385-Great Britain,
pubmed-meshheading:18382385-HIV Infections,
pubmed-meshheading:18382385-HIV-1,
pubmed-meshheading:18382385-Humans,
pubmed-meshheading:18382385-Infant,
pubmed-meshheading:18382385-Mutation, Missense
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pubmed:year |
2008
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pubmed:articleTitle |
HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004.
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pubmed:affiliation |
Paediatric Infectious Diseases Unit, St. George's Hospital, London. rchakrab@sgul.ac.uk
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pubmed:publicationType |
Journal Article
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