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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
The pregnane-X-receptor (PXR) is involved in the metabolism and detoxification of numerous xenobiotics and is critical for maintaining intestinal integrity. The NR1I2 gene encoding PXR may confer susceptibility for Crohn's disease (CD) but evidence for associations is conflicting. We investigated whether the NR1I2 gene was associated with susceptibility for pediatric CD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1536-4844
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pubmed:author |
pubmed-author:AmreDevendra KDK,
pubmed-author:CosteaIrinaI,
pubmed-author:DeslandresColetteC,
pubmed-author:GrimardGuyG,
pubmed-author:IsraelDavidD,
pubmed-author:KrupovesAlfredaA,
pubmed-author:LambrettePhilippeP,
pubmed-author:LevyEmileE,
pubmed-author:MackDavid RDR,
pubmed-author:MorganKennethK,
pubmed-author:SeidmanErnest GEG
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1214-8
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pubmed:meshHeading |
pubmed-meshheading:18381611-Adolescent,
pubmed-meshheading:18381611-Canada,
pubmed-meshheading:18381611-Case-Control Studies,
pubmed-meshheading:18381611-Child,
pubmed-meshheading:18381611-Colitis, Ulcerative,
pubmed-meshheading:18381611-Crohn Disease,
pubmed-meshheading:18381611-Female,
pubmed-meshheading:18381611-Genotype,
pubmed-meshheading:18381611-Haplotypes,
pubmed-meshheading:18381611-Humans,
pubmed-meshheading:18381611-Male,
pubmed-meshheading:18381611-Parents,
pubmed-meshheading:18381611-Phenotype,
pubmed-meshheading:18381611-Polymorphism, Single Nucleotide,
pubmed-meshheading:18381611-Receptors, Steroid
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pubmed:year |
2008
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pubmed:articleTitle |
Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach.
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pubmed:affiliation |
Department of Pediatrics, University of Montreal, Montreal, Canada. devendra.amre@umontreal.ca
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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