Source:http://linkedlifedata.com/resource/pubmed/id/18381463
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
|
pubmed:dateCreated |
2008-4-2
|
pubmed:abstractText |
MicroRNAs (miRNA) are small noncoding RNA molecules involved in a diversity of cellular functions. Although it has been reported that global suppression of the miRNA biogenesis pathway leads to enhanced tumorigenesis, the effect of common genetic variants of miRNA-related genes on cancer predisposition is unclear. To better understand this effect, we genotyped 41 single-nucleotide polymorphisms (SNP) from 24 miRNA-related genes in a case-control study conducted in 746 Caucasian patients with bladder cancer and 746 matched controls. The homozygous variant genotype of a nonsynonymous SNP in the GEMIN3 gene (rs197414) was associated with a significantly increased bladder cancer risk [odds ratios (OR), 2.40; 95% confidence interval (95% CI), 1.04-5.56]. Several additional miRNA-related SNPs were also identified that showed a borderline significant association with bladder cancer risk. Haplotype analysis indicated that a common haplotype of the GEMIN4 gene was associated with a significantly increased bladder cancer risk with an OR of 1.25 (95% CI, 1.01-1.54). To assess the aggregate effects of the promising SNPs, we performed a combined unfavorable genotype analysis that included all SNPs showing at least a borderline statistical significance. We found that, compared with the low-risk reference group with less than two unfavorable genotypes, the medium-risk group with two unfavorable genotypes exhibited a 1.29-fold (0.92-1.81) increased risk whereas the high-risk group with more than two unfavorable genotypes exhibited a 1.92-fold (1.36-2.71) increased risk (P(trend) < 0.0001). Overall, this is the first epidemiologic study showing that miRNA-related genetic variants may affect bladder cancer risk individually and jointly.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1538-7445
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
68
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2530-7
|
pubmed:meshHeading |
pubmed-meshheading:18381463-Adult,
pubmed-meshheading:18381463-Aged,
pubmed-meshheading:18381463-Case-Control Studies,
pubmed-meshheading:18381463-Female,
pubmed-meshheading:18381463-Genetic Predisposition to Disease,
pubmed-meshheading:18381463-Genotype,
pubmed-meshheading:18381463-Haplotypes,
pubmed-meshheading:18381463-Humans,
pubmed-meshheading:18381463-Male,
pubmed-meshheading:18381463-MicroRNAs,
pubmed-meshheading:18381463-Middle Aged,
pubmed-meshheading:18381463-Polymorphism, Single Nucleotide,
pubmed-meshheading:18381463-Urinary Bladder Neoplasms
|
pubmed:year |
2008
|
pubmed:articleTitle |
Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.
|
pubmed:affiliation |
Department of Epidemiology and Urology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|