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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-4-15
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|
pubmed:abstractText |
A novel series of non-hydroxamate HDAC inhibitors (HDACi) showing a uracil group at the left and a 2-aminoanilide/2-aminoanilide-like portion at the right head have been reported. In particular, the new compounds incorporating a 2-aminoanilide moiety behaved as class I-selective HDACi. Compound 8, the most potent and class I-selective, showed weak apoptosis (higher than MS-275) joined to cytodifferentiating activity on U937 cells. Surprisingly, the highest differentiation was observed with 13, through an effect that seems to be unrelated to HDAC inhibition.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
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pubmed:issn |
1464-3405
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
18
|
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2530-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18381238-Acetylation,
pubmed-meshheading:18381238-Amination,
pubmed-meshheading:18381238-Benzamidines,
pubmed-meshheading:18381238-Cell Differentiation,
pubmed-meshheading:18381238-Granulocytes,
pubmed-meshheading:18381238-Histone Deacetylase Inhibitors,
pubmed-meshheading:18381238-Histone Deacetylases,
pubmed-meshheading:18381238-Histones,
pubmed-meshheading:18381238-Humans,
pubmed-meshheading:18381238-Molecular Structure,
pubmed-meshheading:18381238-Recombinant Proteins,
pubmed-meshheading:18381238-Structure-Activity Relationship,
pubmed-meshheading:18381238-U937 Cells,
pubmed-meshheading:18381238-Uracil
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pubmed:year |
2008
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|
pubmed:articleTitle |
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.
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|
pubmed:affiliation |
Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma, Italy. antonello.mai@uniroma1.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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