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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-5-20
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pubmed:abstractText |
Systemic lupus erythematosus (SLE) is an autoimmune disease mainly mediated by the deposit of immune complexes and defects in T lymphocytes and antigen-presenting cells along with a high production of T-helper 2 cytokines. A tolerance-inducible function of nonclassical class Ib human leukocyte antigen (HLA)-G molecule in innate and adaptive cellular responses has been reported, suggesting a role in inflammatory diseases. A 14 bp sequence insertion/deletion polymorphism (rs16375) in the 3'-untranslated region of the HLA-G gene has been associated to the stability of HLA-G messenger RNA. The insertion of the 14 bp sequence seems to be associated with lower levels of soluble HLA-G (sHLA-G). The aim of this study was to evaluate the possible association of the presence of the 14 bp sequence (+14 bp) with SLE. We have HLA-G genotyped 200 SLE patients and 451 healthy control subjects (HS; Italian) and analyzed the plasma levels of sHLA-G and interleukin-10 (IL-10) in a subset of SLE patients and healthy subjects (Italian and Danish). A significant increase of the +14 bp HLA-G allele was detected in the Italian SLE patients compared with HS [P = 0.003, OR 1.44 (95% CI 1.13-1.82)]. A significant increased frequency of HLA-G +14/+14 bp and a decreased frequency of HLA-G -14/-14 bp were observed in SLE patients. There median concentration of sHLA-G was significantly lower in the plasma of SLE patients compared with that in the plasma of healthy controls (P < 0.0001). Furthermore, the results confirmed higher concentrations of IL-10-positive plasma in SLE patients. These results support a potential role for HLA-G in the susceptibility of SLE.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0001-2815
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pubmed:author |
pubmed-author:BaricordiO ROR,
pubmed-author:CarturanSS,
pubmed-author:FerrettiSS,
pubmed-author:FotinidiMM,
pubmed-author:GovoniMM,
pubmed-author:GrappaM TMT,
pubmed-author:HviidT V FTV,
pubmed-author:JunkerPP,
pubmed-author:LaustrupHH,
pubmed-author:MelchiorriLL,
pubmed-author:PadovanMM,
pubmed-author:RizzoRR,
pubmed-author:RubiniMM,
pubmed-author:StignaniMM,
pubmed-author:TrottaFF,
pubmed-author:VossAA
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
520-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18380776-Adult,
pubmed-meshheading:18380776-Antigen-Antibody Complex,
pubmed-meshheading:18380776-Antigen-Presenting Cells,
pubmed-meshheading:18380776-Denmark,
pubmed-meshheading:18380776-Female,
pubmed-meshheading:18380776-Gene Expression Regulation,
pubmed-meshheading:18380776-Genetic Predisposition to Disease,
pubmed-meshheading:18380776-HLA Antigens,
pubmed-meshheading:18380776-HLA-G Antigens,
pubmed-meshheading:18380776-Histocompatibility Antigens Class I,
pubmed-meshheading:18380776-Humans,
pubmed-meshheading:18380776-Immunity, Cellular,
pubmed-meshheading:18380776-Immunity, Innate,
pubmed-meshheading:18380776-Interleukin-10,
pubmed-meshheading:18380776-Italy,
pubmed-meshheading:18380776-Lupus Erythematosus, Systemic,
pubmed-meshheading:18380776-Male,
pubmed-meshheading:18380776-Middle Aged,
pubmed-meshheading:18380776-Polymorphism, Genetic,
pubmed-meshheading:18380776-RNA, Messenger,
pubmed-meshheading:18380776-RNA Stability,
pubmed-meshheading:18380776-Th2 Cells
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pubmed:year |
2008
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pubmed:articleTitle |
HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus.
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pubmed:affiliation |
Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy. rbr@unife.it
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pubmed:publicationType |
Journal Article
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