Linked Life Data

18380000

Source:http://linkedlifedata.com/resource/pubmed/id/18380000

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-1
pubmed:abstractText
Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effect of the occupancy by a ligand molecule of a binding site on further binding steps. However, subsequent development of structural-functional models for the description of the cooperativity in haemoglobin brought about a much deeper information on the interrelationships between ligand binding at the heme and structural variations occurring in the surrounding free subunits. This approach opened the way to the evolution of the concept of allostery, which is intended as the structural-functional effect exerted by the presence of a ligand in a binding site on other binding sites present in the same molecule. This concept can be applied to either sites for the same ligand (homotropic allostery) and for sites of different ligands (heterotropic allostery). Several models trying to take into account the continuous building up of structural and functional information on the physicochemical properties of haemoglobin have been developed along this line.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1521-6543
pubmed:author
pubmed:copyrightInfo
(c) 2008 IUBMB.
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-23
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Cooperativity and allostery in haemoglobin function.
pubmed:affiliation
Department of Experimental Medicine and Biochemical Sciences, University of Roma Tor Vergata, Via Montpellier, Roma, Italy.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't