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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-2-28
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pubmed:abstractText |
N-Ethyl perhexiline (NEP), a drug was synthesized for the first time by Department of Organic Chemistry, Faculty of Chemistry, Beijing University. The effects of NEP on the A-V conduction and intra ventricular conduction were studied in the anesthetized rabbits by recording His bundle electrogram (HBE) and electrocardiogram (ECG). NEP 3 mg.kg-1 iv prolonged A-H, P-R and R-R intervals. When NEP 6 mg.kg-1 was given, the above changes became more significant, with A-H interval from 52 +/- 7 to 65 +/- 9 ms, P-R interval from 65 +/- 6 to 76 +/- 8 ms, R-R interval from 207 +/- 9 to 230 +/- 9 ms, and H-V interval from 19 +/- 3 to 23 +/- 5 ms. The effects of NEP were similar to that of perhexiline, but the effects of NEP on A-H and P-R intervals were stronger. NEP 6 mg.kg-1 iv antagonized shortening effect of nicotinamide 0.5 g.kg-1 on A-H interval in rabbits. When isoproterenol 10 micrograms.kg-1 was given 3 min after NEP 6 mg.kg-1 iv, the A-H interval prolongation induced by NEP was greatly inhibited. The results suggested that the prolongation effects of NEP on A-H, P-R and R-R intervals would be the results of its calcium-channel blockade.
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pubmed:language |
chi
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/N-ethylperhexiline,
http://linkedlifedata.com/resource/pubmed/chemical/Niacinamide,
http://linkedlifedata.com/resource/pubmed/chemical/Perhexiline
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0253-9756
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-70
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pubmed:dateRevised |
2009-2-14
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pubmed:meshHeading |
pubmed-meshheading:1837971-Animals,
pubmed-meshheading:1837971-Bundle of His,
pubmed-meshheading:1837971-Calcium Channel Blockers,
pubmed-meshheading:1837971-Electrocardiography,
pubmed-meshheading:1837971-Female,
pubmed-meshheading:1837971-Isoproterenol,
pubmed-meshheading:1837971-Male,
pubmed-meshheading:1837971-Niacinamide,
pubmed-meshheading:1837971-Perhexiline,
pubmed-meshheading:1837971-Rabbits
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pubmed:year |
1991
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pubmed:articleTitle |
[Effects of N-ethyl perhexiline on His bundle electrogram in rabbits].
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pubmed:affiliation |
Department of Pharmacology, School of Basic Medical Science, Beijing Medical University, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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