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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-4-15
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pubmed:abstractText |
The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2594-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18378445-Animals,
pubmed-meshheading:18378445-Benzimidazoles,
pubmed-meshheading:18378445-Benzodiazepines,
pubmed-meshheading:18378445-Cattle,
pubmed-meshheading:18378445-Cell Line, Tumor,
pubmed-meshheading:18378445-Cell Survival,
pubmed-meshheading:18378445-DNA,
pubmed-meshheading:18378445-Humans,
pubmed-meshheading:18378445-Molecular Structure,
pubmed-meshheading:18378445-Nucleic Acid Denaturation,
pubmed-meshheading:18378445-Pyrroles,
pubmed-meshheading:18378445-Structure-Activity Relationship,
pubmed-meshheading:18378445-Temperature
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity.
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pubmed:affiliation |
Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.res.in
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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