Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-6-9
pubmed:abstractText
Sympathetic nervous system and atrial natriuretic peptide (ANP) system play fundamental roles in the regulation of cardiovascular functions. Overactivity of sympathetic nervous system can lead into cardiovascular diseases such as heart failure and hypertension. The present study aimed to define which adrenergic receptors (ARs) affect atrial contractility and ANP release and to determine their modification in renal hypertensive rat atria. An alpha(1)-AR agonist, cirazoline increased ANP release with positive inotropism. These alpha(1)-AR agonist-mediated responses were attenuated by the alpha(1A)-AR antagonist, but not by the alpha(1B)- or alpha(1D)-AR antagonist. An alpha(2)-AR agonist, guanabenz and clonidine increased ANP release with negative inotropism and decreased cAMP level. The order of potency for the increased ANP release was cirazoline>>phenylephrine=guanabenz>>clonidine. In contrast, a beta-AR agonist, isoproterenol decreased ANP release with positive inotropism and these responses were blocked by the beta(1)-AR antagonist but not by the beta(2)-AR antagonist. The increased cAMP level by isoproterenol was suppressed by pretreatment with both beta(1)- and beta(2)-AR antagonists. In renal hypertensive rat atria, the effects of isoproterenol on atrial contractility, ANP release, and cAMP level were attenuated whereas the effect of cirazoline on ANP release was unaltered. Atrial beta(1)-AR mRNA level but not alpha(1A)-AR mRNA level was decreased in renal hypertensive rats. These findings suggest that alpha(1A)- and beta(1)-AR oppositely regulate atrial ANP release and that atrial beta(1)-AR expression/function is impaired in renal hypertensive rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor, http://linkedlifedata.com/resource/pubmed/chemical/Clonidine, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Guanabenz, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol, http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, http://linkedlifedata.com/resource/pubmed/chemical/cirazoline
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0196-9781
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1207-15
pubmed:meshHeading
pubmed-meshheading:18378355-Adrenergic alpha-Agonists, pubmed-meshheading:18378355-Adrenergic beta-Agonists, pubmed-meshheading:18378355-Animals, pubmed-meshheading:18378355-Atrial Natriuretic Factor, pubmed-meshheading:18378355-Clonidine, pubmed-meshheading:18378355-Cyclic AMP, pubmed-meshheading:18378355-Dose-Response Relationship, Drug, pubmed-meshheading:18378355-Guanabenz, pubmed-meshheading:18378355-Heart Atria, pubmed-meshheading:18378355-Hypertension, Renal, pubmed-meshheading:18378355-Imidazoles, pubmed-meshheading:18378355-Isoproterenol, pubmed-meshheading:18378355-Male, pubmed-meshheading:18378355-Phenylephrine, pubmed-meshheading:18378355-RNA, Messenger, pubmed-meshheading:18378355-Radioligand Assay, pubmed-meshheading:18378355-Rats, pubmed-meshheading:18378355-Rats, Sprague-Dawley, pubmed-meshheading:18378355-Receptors, Adrenergic, pubmed-meshheading:18378355-Time Factors
pubmed:year
2008
pubmed:articleTitle
Different response of ANP secretion to adrenoceptor stimulation in renal hypertensive rat atria.
pubmed:affiliation
Department of Physiology, Medical School, Chonbuk National University, Jeonju 561-180, Republic of Korea.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't