Linked Life Data

18377726

Source:http://linkedlifedata.com/resource/pubmed/id/18377726

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-4-1
pubmed:abstractText
Reactive oxygen species (ROS) are implicated in vascular homeostasis. This study investigated whether O(2) (*-), the foundationmolecule of all ROS, regulates vasomotor function. Hence, vascular reactivity was measured using rat thoracic aortas exposed to an O(2) (*-) generator (pyrogallol) which dose-dependently regulated both alpha-adrenergic agonist-mediated contractility to phenylephrine and endothelium-dependent relaxations to acetylcholine. Pyrogallol improved and attenuated responses to acetylcholine at its lower (10 nM - 1 microM) and higher (10 - 100 microM) concentrations, respectively while producing the inverse effects with phenylephrine. The endothelial inactivation by L-NAME abolished acetylcholine-induced vasodilatations but increased phenylephrine and KCl-induced vasoconstrictions regardless of the pyrogallol dose used. Relaxant responses to sodium nitroprusside, a nitric oxide donor, were not affected by pyrogallol. Other ROS i.e. peroxynitrite and H(2)O(2) that may be produced during experiments did not alter vascular functions. These findings suggest that the nature of O(2) (*-)-evoked vascular function is determined by its local concentration and the presence of a functional endothelium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1976-6696
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-9
pubmed:dateRevised
2009-4-27
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The bimodal regulation of vascular function by superoxide anion: role of endothelium.
pubmed:affiliation
Department of Medicine and Therapeutics, Institute of Clinical Science, Queen's University Belfast, Belfast, UK.
pubmed:publicationType
Journal Article, In Vitro