Linked Life Data

18376126

Source:http://linkedlifedata.com/resource/pubmed/id/18376126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-9-1
pubmed:abstractText
Inflammation has been indicated to play a major role in the development of atherosclerosis. The beneficial effect of statins has been suggested to be related to their anti-inflammatory properties. We have studied plasma levels of soluble adhesion molecules in patients with hypercholesterolemia before and after 3 months of treatment with atorvastatin and evaluated possible relations to the mutations in low-density lipoprotein receptor (LDLR) gene. In patients with no LDLR gene polymorphism (group A), lower baseline levels of total cholesterol and LDL cholesterol were found than in patients with LDLR gene polymorphism (group B). The soluble adhesion molecules sICAM-1, sE-selectin and sP-selectin, but not sVCAM-1 and sL-selectin, were higher in group B than in group A. sICAM-1 levels decreased in group A by 7% (p = 0.007) and in group B by 21% (p = 0.039), whereas levels of sVCAM-1 decreased in group A by 12% (p = 0.001) and in group B patients by 19% (p = 0.039). Atorvastatin did not change sE-selectin nor sP-selectin levels in group A. However, in group B, the treatment reduced E-selectin and sP-selectin levels by 39% (p = 0.007) and 24% (p = 0.007), respectively. Atorvastatin attenuates the inflammatory reaction in hypercholesterolemic patients, but in patients with LDLR gene polymorphism, this effect is more profound.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1421-9751
pubmed:author
pubmed:copyrightInfo
Copyright 2008 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
140-6
pubmed:meshHeading
pubmed-meshheading:18376126-Adult, pubmed-meshheading:18376126-Aged, pubmed-meshheading:18376126-Anticholesteremic Agents, pubmed-meshheading:18376126-Cholesterol, HDL, pubmed-meshheading:18376126-Cholesterol, LDL, pubmed-meshheading:18376126-Dose-Response Relationship, Drug, pubmed-meshheading:18376126-Drug Administration Schedule, pubmed-meshheading:18376126-E-Selectin, pubmed-meshheading:18376126-Female, pubmed-meshheading:18376126-Follow-Up Studies, pubmed-meshheading:18376126-Gene Expression Regulation, pubmed-meshheading:18376126-Heptanoic Acids, pubmed-meshheading:18376126-Humans, pubmed-meshheading:18376126-Hypercholesterolemia, pubmed-meshheading:18376126-Inflammation Mediators, pubmed-meshheading:18376126-Intercellular Adhesion Molecule-1, pubmed-meshheading:18376126-Male, pubmed-meshheading:18376126-Middle Aged, pubmed-meshheading:18376126-Polymorphism, Genetic, pubmed-meshheading:18376126-Probability, pubmed-meshheading:18376126-Prospective Studies, pubmed-meshheading:18376126-Pyrroles, pubmed-meshheading:18376126-Receptors, LDL, pubmed-meshheading:18376126-Reference Values, pubmed-meshheading:18376126-Severity of Illness Index, pubmed-meshheading:18376126-Treatment Outcome
pubmed:year
2008
pubmed:articleTitle
The effect of atorvastatin treatment on lipid profile and adhesion molecule levels in hypercholesterolemic patients: relation to low-density lipoprotein receptor gene polymorphism.
pubmed:affiliation
Pozna? Medical University, Cardiac and Rehabilitation Hospital Kowanowko, Pozna?, Poland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't