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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-29
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pubmed:abstractText |
We have previously demonstrated that modulation of gamma-aminobutyric acid (GABA) inhibitory tone in the ventromedial hypothalamus (VMH), an important glucose-sensing region in the brain, modulates the magnitude of glucagon and sympathoadrenal responses to hypoglycemia. In the current study, we examined whether increased VMH GABAergic tone may contribute to suppression of counterregulatory responses after recurrent hypoglycemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1363-70
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:18375441-Animals,
pubmed-meshheading:18375441-DNA Primers,
pubmed-meshheading:18375441-Disease Models, Animal,
pubmed-meshheading:18375441-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18375441-Glucose Clamp Technique,
pubmed-meshheading:18375441-Glutamate Decarboxylase,
pubmed-meshheading:18375441-Hypoglycemia,
pubmed-meshheading:18375441-Male,
pubmed-meshheading:18375441-RNA, Messenger,
pubmed-meshheading:18375441-Rats,
pubmed-meshheading:18375441-Rats, Sprague-Dawley,
pubmed-meshheading:18375441-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18375441-Ventromedial Hypothalamic Nucleus,
pubmed-meshheading:18375441-gamma-Aminobutyric Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.
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pubmed:affiliation |
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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