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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-9-9
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pubmed:abstractText |
Carriers of a particular haplotype of the GTP cyclohydrolase gene (GCH1) had less pain after surgery for chronic lumbar radiculopathy and a decreased sensitivity to some experimental mechanical pain stimuli. Ex-vivo, GCH1 upregulation and BH4 production after forskolin stimulation were reduced, while baseline BH4 concentrations were not affected. This suggested that the haplotype may mainly exert its modulating function when the GCH1 system is provoked. The present study aimed at (i) testing this hypothesis and (ii) independently reproducing the pain-decreasing effects of a particular GCH1 haplotype having been previously associated with pain protection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1532-2149
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1069-77
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18374612-Adult,
pubmed-meshheading:18374612-Biopterin,
pubmed-meshheading:18374612-DNA Mutational Analysis,
pubmed-meshheading:18374612-Female,
pubmed-meshheading:18374612-Forskolin,
pubmed-meshheading:18374612-GTP Cyclohydrolase,
pubmed-meshheading:18374612-Genetic Predisposition to Disease,
pubmed-meshheading:18374612-Genetic Testing,
pubmed-meshheading:18374612-Haplotypes,
pubmed-meshheading:18374612-Heterozygote,
pubmed-meshheading:18374612-Homozygote,
pubmed-meshheading:18374612-Humans,
pubmed-meshheading:18374612-Hyperalgesia,
pubmed-meshheading:18374612-Low Back Pain,
pubmed-meshheading:18374612-Male,
pubmed-meshheading:18374612-Neurosurgical Procedures,
pubmed-meshheading:18374612-Pain Measurement,
pubmed-meshheading:18374612-Pain Threshold,
pubmed-meshheading:18374612-Radiculopathy
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pubmed:year |
2008
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pubmed:articleTitle |
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.
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pubmed:affiliation |
Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
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pubmed:publicationType |
Journal Article
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