Linked Life Data

18374169

Source:http://linkedlifedata.com/resource/pubmed/id/18374169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-3-31
pubmed:abstractText
This chapter describes methods for the analysis of B and T lymphocyte development in mice deficient in Rac1 and/or Rac2 GTPases. The development of both B and T cells is critically dependent on transition through checkpoints monitoring for correct rearrangement of antigen receptor genes. Progression through these checkpoints depends on signaling from the antigen receptors. In addition, signals from cytokine, chemokine, Notch, and death receptors play important roles in the survival, proliferation, and migration of developing lymphocytes. Analysis of these processes in mice deficient in these GTPases can illuminate their roles in transducing signals from these different receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0076-6879
pubmed:author
pubmed:issnType
Print
pubmed:volume
439
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-54
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.
pubmed:affiliation
Division of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't