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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-7-28
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pubmed:abstractText |
Excessive angiogenesis plays critical roles in many human diseases including cancer. We have previously shown that human decorin derived 26 amino acids peptide Leucine Rich Repeat 5 (LRR5) inhibits multiple aspects of angiogenesis including vascular endothelial growth factor (VEGF) stimulated migration of endothelial cells (ECs). In this study, we have characterized the molecular mechanism of LRR5 which reveals that its anti-migratory effect on ECs is mediated by inhibiting VEGF-stimulated endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) release. LRR5 carried out this function through signaling pathways that involves PI3 kinase and Akt, but not ERK. This anti-NO release effect is mediated by the C-terminal 13 amino acids of LRR5, correlating with the anti-migratory function of this region.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/DCN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Decorin,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoserine,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/leucine-rich repeat proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
1357-2725
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2120-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18373940-Angiogenesis Inhibitors,
pubmed-meshheading:18373940-Cell Movement,
pubmed-meshheading:18373940-Cells, Cultured,
pubmed-meshheading:18373940-Decorin,
pubmed-meshheading:18373940-Endothelial Cells,
pubmed-meshheading:18373940-Enzyme Activation,
pubmed-meshheading:18373940-Extracellular Matrix Proteins,
pubmed-meshheading:18373940-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18373940-Humans,
pubmed-meshheading:18373940-Models, Biological,
pubmed-meshheading:18373940-Nitric Oxide,
pubmed-meshheading:18373940-Nitric Oxide Synthase Type III,
pubmed-meshheading:18373940-Peptides,
pubmed-meshheading:18373940-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18373940-Phosphorylation,
pubmed-meshheading:18373940-Phosphoserine,
pubmed-meshheading:18373940-Proteins,
pubmed-meshheading:18373940-Proteoglycans,
pubmed-meshheading:18373940-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18373940-Vascular Endothelial Growth Factor A
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pubmed:year |
2008
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pubmed:articleTitle |
Decorin derived antiangiogenic peptide LRR5 inhibits endothelial cell migration by interfering with VEGF-stimulated NO release.
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pubmed:affiliation |
Department of Biological Sciences, National University of Singapore, BLK S2, 05-04, Science Drive 4, Singapore 117543, Singapore. fanhuapeng@nus.edu.sg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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