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pubmed:abstractText |
Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is associated with TH2 immune responses, which in helminth infections are controlled primarily by IL-13, and also IL-4. In the study presented here we examine the goblet cell hyperplasic response to three experimental parasitic helminth infections; namely Nippostrongylus brasiliensis, Syphacia obvelata and Schistosoma mansoni.
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pubmed:affiliation |
Division of Immunology, Institute of Infectious disease and Molecular Medicine, Health Sciences Faculty, University of Cape Town, 7925 Cape Town, South Africa. reece.marillier@uct.ac.za
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