Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-3-28
pubmed:abstractText
A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor. Here, we describe the identification and characterization of such cells from colon carcinomas using the stem cell marker CD133 that accounts around 2% of the cells in human colon cancer. The CD133(+) cells grow in vitro as undifferentiated tumor spheroids, and they are both necessary and sufficient to initiate tumor growth in immunodeficient mice. Xenografts resemble the original human tumor maintaining the rare subpopulation of tumorigenic CD133(+) cells. Further analysis revealed that the CD133(+) cells produce and utilize IL-4 to protect themselves from apoptosis. Consistently, treatment with IL-4Ralpha antagonist or anti-IL-4 neutralizing antibody strongly enhances the antitumor efficacy of standard chemotherapeutic drugs through selective sensitization of CD133(+) cells. Our data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1875-9777
pubmed:author
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-402
pubmed:dateRevised
2009-5-20
pubmed:meshHeading
pubmed-meshheading:18371377-Aged, pubmed-meshheading:18371377-Animals, pubmed-meshheading:18371377-Antigens, CD, pubmed-meshheading:18371377-Antineoplastic Agents, pubmed-meshheading:18371377-Cell Death, pubmed-meshheading:18371377-Cell Line, Tumor, pubmed-meshheading:18371377-Colonic Neoplasms, pubmed-meshheading:18371377-Female, pubmed-meshheading:18371377-Fluorouracil, pubmed-meshheading:18371377-Glycoproteins, pubmed-meshheading:18371377-Humans, pubmed-meshheading:18371377-Interleukin-4, pubmed-meshheading:18371377-Male, pubmed-meshheading:18371377-Mice, pubmed-meshheading:18371377-Mice, Nude, pubmed-meshheading:18371377-Middle Aged, pubmed-meshheading:18371377-Neoplastic Stem Cells, pubmed-meshheading:18371377-Neutralization Tests, pubmed-meshheading:18371377-Organoplatinum Compounds, pubmed-meshheading:18371377-Peptides, pubmed-meshheading:18371377-Receptors, Interleukin-4, pubmed-meshheading:18371377-Spheroids, Cellular, pubmed-meshheading:18371377-Xenograft Model Antitumor Assays
pubmed:year
2007
pubmed:articleTitle
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
pubmed:affiliation
Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't