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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-2-12
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pubmed:abstractText |
This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
14
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1837072-Animals,
pubmed-meshheading:1837072-Corpus Striatum,
pubmed-meshheading:1837072-Desipramine,
pubmed-meshheading:1837072-Dopamine,
pubmed-meshheading:1837072-Male,
pubmed-meshheading:1837072-Nerve Degeneration,
pubmed-meshheading:1837072-Neural Pathways,
pubmed-meshheading:1837072-Oxidopamine,
pubmed-meshheading:1837072-Quinolinic Acid,
pubmed-meshheading:1837072-Quinolinic Acids,
pubmed-meshheading:1837072-Rats,
pubmed-meshheading:1837072-Rats, Inbred Strains,
pubmed-meshheading:1837072-Substantia Nigra
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pubmed:year |
1991
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pubmed:articleTitle |
Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.
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pubmed:affiliation |
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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