Linked Life Data

18370160

Source:http://linkedlifedata.com/resource/pubmed/id/18370160

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-3-28
pubmed:abstractText
Dendritic cells (DCs) are crucial in adaptive immunity because they are the only antigen-presenting cells that can present antigens to naive T lymphocytes. Plasmacytoid DCs (pDC) are also the main producers of type I Interferons in response to infection. We have shown that circulating myeloid DC (mDC) and pDC numbers are reduced in chronic as well as primary HIV infection. Data from different laboratories indicate that pDC counts, obtained by flow cytometry and rare event analysis, correlate inversely with the viral load, may be an early marker of recovery after antiretroviral treatment, and may predict better immune control of HIV replication. PDC counts may also be predictive of severe illness in dengue virus infection or of successful treatment against Mycobacterium tuberculosis. DC counts, or the "dendritogram", may therefore become useful in the clinical assessment of different infectious diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
415
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-90
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Clinical analysis of dendritic cell subsets: the dendritogram.
pubmed:affiliation
Institut Cochin, Département d'Immunologie, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't